Immunochemical analysis of kinesin light chain function.
نویسندگان
چکیده
منابع مشابه
Kinesin light chain-independent function of the Kinesin heavy chain
In Drosophila, the asymmetries that specify the embryonic axes are established early during oogenesis in a process that requires the precise localisation of several transcripts (Riechmann and Ephrussi, 2001; van Eeden and St Johnston, 1999). The localisation of oskar mRNA to the posterior pole of the oocyte specifies where the pole plasm forms, and thus where the abdomen and the germ line will ...
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Microtubules and the Kinesin heavy chain, the force-generating component of the plus end-directed microtubule motor Kinesin I are required for the localisation of oskar mRNA to the posterior pole of the Drosophila oocyte, an essential step in the determination of the anteroposterior axis. We show that the Kinesin heavy chain is also required for the posterior localisation of Dynein, and for all...
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Conventional kinesin, kinesin-I, is a heterotetramer of two kinesin heavy chain (KHC) subunits (KIF5A, KIF5B, or KIF5C) and two kinesin light chain (KLC) subunits. While KHC contains the motor activity, the role of KLC remains unknown. It has been suggested that KLC is involved in either modulation of KHC activity or in cargo binding. Previously, we characterized KLC genes in mouse (Rahman, A.,...
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The molecular motor kinesin is an ATPase that mediates plus end-directed transport of organelles along microtubules. Although the biochemical properties of kinesin are extensively studied, conclusive data on regulation of kinesin-mediated transport are largely lacking. Previously, we showed that the proinflammatory cytokine tumor necrosis factor induces perinuclear clustering of mitochondria. H...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 1997
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.8.4.675